The principles of minimally invasive atrioventricular valve repair surgery utilizing endoaortic balloon occlusion technology: how to start and sustain a safe and effective program
Review Article on Cardiac Surgery

The principles of minimally invasive atrioventricular valve repair surgery utilizing endoaortic balloon occlusion technology: how to start and sustain a safe and effective program

Johan Van der Merwe, Filip Casselman, Frank Van Praet

Department of Cardiovascular and Thoracic Surgery, OLV Clinic, Aalst, Belgium

Contributions: (I) Conception and design: J van der Merwe, F Casselman; (II) Administrative support: None; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: J van der Merwe, F Casselman; (V) Data analysis and interpretation: J van der Merwe, F Casselman; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

Correspondence to: Filip Casselman, MD, PhD, FETCS. Department of Cardiovascular and Thoracic Surgery, OLV Clinic, Moorselbaan 164, 9300, Aalst, Belgium. Email:

Abstract: The ongoing evolution in therapeutic transcatheter (TC) and minimally invasive surgical technology for atrioventricular valve (AVV) disease is paralleled by an aging- and higher surgical risk patient population, increasing public expectations, quality control and clinical governance. International treatment guidelines and changes in referral patterns progressively favour less invasive procedures, which require that both current- and future cardiac surgical practices become proficient in minimally invasive atrioventricular valve surgical (MIAS) and TC procedures. The transition from classic sternotomy access to MIAS approaches that utilizes videoscopic- or robotic vision, modified long-shafted instruments, transoesophageal echocardiographic- (TEE) or fluoroscopic guidewire directed peripheral cardiopulmonary bypass (CPB) and endo-aortic balloon occlusion device placement [Port Access™ Surgery (PAS)] are associated with learning curves that are challenging to master in an era of decreasing surgical volume, training opportunities and healthcare cost constraints. Excellent perioperative- and long term outcomes with the routine application of MIAS utilizing PAS technology for isolated primary- and redo-AVV procedures are reported and it is suggested that the introduction of PAS in new centres should follow a systematic approach that include careful infrastructure planning, MIAS and PAS skills development and careful initial patient selection criteria under expert guidance. This manuscript provides an overview of the historic evolution of PAS, contemporary PAS technology, PAS infrastructure planning and the operative principles of PAS with the intention of assisting upcoming centres to establish and maintain safe- and effective PAS programs.

Keywords: Minimally invasive cardiac surgery; mitral valve; tricuspid valve; risk management

Received: 16 July 2019; Accepted: 22 July 2019; Published: 30 August 2019.

doi: 10.21037/jovs.2019.08.01


Transcatheter- (TC) and minimally invasive atrioventricular valve surgical (MIAS) technology are rapidly evolving and are paralleled by increasing patient expectations (1), quality control (2), clinical governance (3) and patient risk profiles (4). In an era of decreasing surgical volume, training opportunities, operative exposure and constrains in healthcare cost, upcoming surgeons are required to master challenging MIAS learning curves while maintaining acceptable clinical outcomes (5,6). It is now well recognised that both current- and future cardiac surgical practices will be expected to be proficient in MIAS and TC device implantation (7,8), but the implementation and maintenance or such programs require systematic logistical and infrastructure planning. Port Access™ atrioventricular valve surgery (PAS) utilizes videoscopic- or robotic vision, modified instruments, transoesophageal echocardiographic- (TEE) or fluoroscopic guided peripheral cardiopulmonary bypass (CPB) and endo-aortic balloon technology or external aortic clamping techniques to facilitate primary- (9,10) and redo- (11,12) MIAS repair- and replacement procedures. Between February 1st 1998 and May 31st 2019, a total of 3,180 patients underwent PAS procedures at our institution for isolated atrioventricular valve (AVV) pathology. This manuscript provides an overview of the historic evolution of PAS, contemporary PAS technology, PAS infrastructure planning and the operative principles of PAS to assist new centres to establish and maintain safe- and effective PAS programs.

Historical evolution of port access™ surgery (PAS)

The concept of PAS was originally developed in 1994 (Heartport Inc., Redwood City, CA, USA) with the intention of using any combination of central- or peripheral CPB, endo-aortic balloon occlusion-, retrograde cardioplegia- and pulmonary artery venting catheter devices to facilitate minimally invasive cardiac surgical procedures. Animal studies at Stanford- and New York University (13) demonstrated PAS feasibility and safety with subsequent United States Food and Drug Administration approval in 1996 Ame (14-17). More than 18,000 minimally invasive cardiac procedures, which included coronary artery bypass grafting, were performed using components of PAS technology between 1996 and 2000 and its ergonomic advantage of allowing MIAS through small working ports without additional external instrumentation (18-20), especially in total endoscopic- (21-23) and robotic surgery (24,25), became well recognised. Edwards Lifesciences (Irvine, California, USA) subsequently took ownership of PAS and recently reported a global use of PAS technology in 12,689 patients between 2014 and 2017.

Current port access™ technology

IntraClude™ (Edwards Lifesciences, Irvine, California, USA) is a composite endo-aortic balloon occlusion device (10.5 Fr, 100 cm length) that facilitates antegrade cardioplegia delivery, aortic root venting and pressure monitoring for ascending aorta sizes ranging 20–40 mm (Figure 1A). It is advanced to the sino-tubular junction under TEE- or fluoroscopic guidance over a 200 cm 0.0038 J-tip guidewire through the side arm of the EndoReturn™ femoral arterial cannula (21–23 Fr, Edwards Lifesciences, Irvine, California, USA) (Figure 1B). The QuickDraw™ femoral venous cannula (22–25 Fr, Edwards Lifesciences, Irvine, California, USA) is inserted under TEE or fluoroscopic guidance into the right atrium and is compatible with percutaneous approaches. The ProPlege™ peripheral retrograde cardioplegia device (9 Fr, 59 cm, Edwards Lifesciences, Irvine, California, USA), is a triple lumen device that is inserted through an internal jugular vein sheath into the coronary sinus under TEE guidance as an adjunct to endo-aortic balloon occlusion for additional retrograde cardioplegia delivery (Figure 1C). The EndoVent™ pulmonary catheter (8.3 Fr, Edwards Lifesciences, Irvine, California, USA) is inserted though the internal jugular- or subclavian vein as an additional endo-pulmonary artery venting device (Figure 1D). Optisite™ (17 Fr, Edwards Lifesciences, Irvine, California, USA) is a peripheral cannula that can be utilized for additional arterial cannulation in cases of high CPB flow pressures. Special atrial retractors facilitate intracardiac access to perform robotic- or endoscopic AVV repair and replacement procedures.

Figure 1 Current Port Access™ surgery technology include (A) an endo-aortic balloon occlusion device (Intraclude™); (B) a peripheral arterial cannula with side arm (EndoReturn™); (C) a peripheral coronary sinus cardioplegia device (Proplege™); and (D) a peripheral pulmonary artery vent catheter (Endovent™). Reproduced with permission from Edwards Lifesciences (Irvine, California, USA).

Infrastructure planning

PAS health care economics

Evidence of proven efficacy, safety, feasibility and cost-effectiveness are required to obtain institutional support as a first step in initiating a PAS program. Atluri (26) and Santana (27) independently suggested that the greater operative cost associated with MIAS is offset by reduced costs of cardiac imaging, laboratory tests, lower use of blood products, fewer perioperative infections, faster recovery, shorter hospital length of stay, fewer requirements for rehabilitation and lower readmission rates. Equipment acquisition- and operative theatre upgrades account for the majority of the initial institutional capital investment and the disposable costs can subsequently be offset against the cost savings mentioned.

PAS and hybrid operative theatre design

Modern MIAS- and hybrid cardiovascular- and thoracic operating rooms are designed to facilitate TC and MIAS procedures in conjunction with efficient workflow, safety, access, lights, imaging modalities and theatre hygiene. Building a “state of the art” hybrid operating room (Figure 2) is a considerable economic investment for every institution, but various reports from the United States and China (28), suggest that case load potentially triple based upon the hybrid theatre setup, with a complete return on investment within 2 years. For PAS, the basic operative room layout must be able to accommodate a cardiac anaesthetic- and TEE machine, an endoscopic camera- and CO2 delivery stack, a CPB machine, various synchronised screens for neuro-cardio-respiratory-, TEE- and 2D and 3D endoscopic image projection and adequate ergonomics that can accommodate 2 anaesthetists, 2 perfusionists, 2 surgeons, a theatre nurse and a support nurse. It is imperative that all routine cardiovascular equipment, guidewires, grafts, stents and sutures are readily available if required.

Figure 2 Endoscopic atrioventricular valve surgery logistics. Hybrid Port Access™ and minimally invasive atrioventricular valve surgery operative theatre layout (A); Port Access™ surgery performed using 3D imaging technology (B).

Teamwork, communication, ownership and leadership

To promote trust, communication, effective teamwork, training and education, established PAS centres advocate a patient-centred-, multidisciplinary cardiac operative team that include an experienced anaesthesiologist (29), perfusionist (30), a skilled cardiac surgeon, surgical assistant, an experienced operative nurse and cardiac nursing support. It is suggested that a dedicated theatre team visit established PAS centres for training and mentorship and that a constant team initiate the PAS program for at least 20 cases (31). Frequent constructive postoperative team debriefing sessions that focus on continuous improvement strategies are invaluable and reinforces ownership of each team member under the surgical leadership. Intraoperative communication is essential and each team member`s opinion and concerns should be respected and addressed throughout any PAS procedure. For continuation of postoperative care, the expanded team members include skilled intensive care-, ward- and outpatient nurses, physiotherapists, other allied health care professionals, the patient family and referring physicians.

Patient selection

In an era where surgical volume is progressively decreasing, emerging PAS programs should practice extreme caution in the initial patient- and valve pathology selection. Even though PAS is applied as a routine in experienced centres without exclusion criteria (32-37), it is suggested that emerging programs should preferably not offer PAS to patients with high risk clinical-, anatomical- and echocardiographic characteristics, which are outlined in Table 1. In addition to routine cardiac surgical preoperative investigations, evaluation of the aorta-iliac-femoral arterial-axis by contrasted computerised tomography, magnetic resonance imaging or an additional peripheral contrast injection during coronary angiography, is mandatory. In 511 consecutive patients that underwent PAS in an experience centre over a 5-year period, lung adhesions (n=5, 1.0%) and peripheral cannulation complications (n=4, 0.8%) required sternotomy conversion despite detailed preoperative evaluations (38).

Table 1
Table 1 Relative contraindications to initial Port Access™ Surgery patient selection
Full table

Procedural overview

Patient positioning and port incisions

The patient is positioned supine with the right arm flexed and external defibrillation pads applied. An inflatable cushion is used to elevate the right hemithorax following routine cardiac anaesthesia that includes the insertion of a double lumen endotracheal tube, right internal jugular central venous- and right radial artery catheters, urinary catheter, rectal temperature monitoring and TEE probe. It is advised to utilise a right internal jugular venous cannula (16–18 Fr, Optisite™, Edwards Lifesciences, Irvine, California, USA) as additional venous drainage during the learning period. Various experienced centres however, rely only on single femoral venous cannulation augmented by vacuum assisted drainage. The use of bilateral radial artery catheter monitoring may be used during the early experience to ensure continuous hemodynamic monitoring in case of aortic dissection or endo-balloon dislodgement that may occlude the innominate artery. A 4-6 cm, non-rib spreading working port with a soft tissue retractor (SurgiSleeve™, 2.5–6 centimeters, Covidien, Massachusetts, USA) is established over the 4th intercostal, anterior axillary space, halfway between the clavicle and inferior xyphoid-costal border. The diaphragmatic dome should be palpable. A 7-mm port is inserted 2 to 3 intercostal spaces inferior to the working port for continuous CO2 insufflation and left atrial vent line placement. A 5-mm endoscopic port- and a 5-mm left atrial retractor shaft are inserted latero-posteriorly- and parasternal-medially to the working port in the 4th intercostal space respectively (Figure 3A). The retractor-shaft is externally anchored to a Bookwalther™ retractor (Symmetry Surgical, Tennessee, USA) and a steel wire introduced through a needle in 2nd intercostal space, mid-clavicular line to facilitate valve exposure by retracting annuloplasty sutures anterolaterally. Unobstructed visual- and working access are ascertained by resecting excessive pericardial fat (Figure 3B) and retracting the diaphragmatic dome infero-laterally with exteriorized traction sutures. The additional use of retrograde coronary sinus cannulation for cardioplegia delivery (ProPlege™) and pulmonary artery venting (EndoVent™) can be considered, but is not generally utilized during the initial learning curve (Figure 3C).

Figure 3 Surgical preparations. (A) Standard Port Access™ surgery setup, with (B) endoscopic pericardial exposure and (C) use of a peripheral coronary sinus cardioplegia- and pulmonary vent device.

Peripheral vascular cannulation and IntraClude™ positioning

A 4-cm right groin incision provides access to the right common femoral artery and vein during which care is taken to avoid the medial lymphatic rich regions. Following systemic heparinization and confirmation of an activated clotting time more than 400 seconds, the femoral vein is punctured first by using the Seldinger technique. A radio-opaque guidewire is inserted into the right atrium under TEE or fluoroscopic guidance, after which the Quickdraw™ venous cannula is advanced over the guidewire and secured with the cannula tip adjacent to the intraatrial septum. Vacuum assist venous drainage is a necessary adjunct for femoral venous cannulation. The common femoral artery is similarly punctured above the deep branch bifurcation followed by the TEE guided insertion of a guidewire into the descending aorta. The artery is subsequent dilated and an appropriately sized EndoReturn™ cannula inserted, de-aired, secured and observed for pulsatile waveforms. The use of peripheral limb saturation monitoring is suggested to monitor for leg ischemia during peripheral CPB, but the routine use of distal perfusion strategies, which include additional cannulation, is controversial and not generally advocated. The Intraclude™ catheter device is inserted through the Endoreturn™ side-arm, de-aired and carefully advanced over its guidewire across the descending aorta, the aortic arch and into the ascending aorta under TEE guidance and is then locked into position (Figure 4A). Total percutaneous cannulation using vascular closure devices (39) can be performed as a favourable alternative (Figure 4B), but is not advocated if inexperienced. Peripheral vascular spasm may occur and can be identified by dampening of the arterial curve on the CPB machine, which then requires contralateral cannulation. This is achieved with the insertion of an Optisite™ cannula in the left common femoral artery, which is then connected to the Endoreturn™ tubing in a Y-configuration arterial inflow circuit. CPB- and systemic hypothermia to 32 degrees Celsius are carefully initiated. CPB pressures more than 300 mmHg require temporary flow cessation and contralateral cannulation as described. It is reported that insufficient CPB flow occur in 0.2%-, guidewire resistance in 0.6%- and cannulation related aortic dissection in 0.2% of PAS procedures, which emphasises the importance of meticulous preoperative aorta-iliac-femoral-axis evaluation, access planning and careful guidewire manipulation techniques (40). Central aortic cannulation by sternotomy conversion is advocated to ensure patient safety in cases of concern or persistent difficulty. Alternative cannulation access, which includes right axillary artery or direct central aortic cannulation, is not advised for the initial PAS learning experience. Peripheral saturation monitoring of the cannulated limb should be mandatory to detect hypoperfusion and the routine use an additional distal perfusion cannula is utilised in some centres.

Figure 4 Peripheral cardiopulmonary bypass using classic (A) open and (B) total percutaneous access.

Atrial exposure and preparation

Once safe CPB is ascertained, a longitudinal pericardiotomy is performed above the phrenic nerve, with subsequent exteriorised retraction sutures used to provide unobstructed endoscopic views and working port access of the superior- and inferior vena cava, aorta, atria and interatrial groove (Figure 5A). An additional suspension suture on the intraatrial groove provides additional exposure for an uncomplication left atriotomy. The oblique sinus is exposed and the intraatrial groove developed in preparation for atriotomy (Figure 5B).

Figure 5 Intrapericardial preparations. (A) Intrapericardial exposure and (B) development of the oblique sinus.

IntraClude™ inflation, antegrade cardioplegia delivery and venting (Figure 6)

Figure 6 Endo-aortic balloon inflation under transesophageal echocardiographic guidance (41). Available online:

Once all team members confirm satisfactory parameters and readiness, the assisting surgeon stabilises the EndoReturn™ cannula with his/her right hand, the IntraClude™ device position is reconfirmed by TEE, partially inflated to approximately 75% of the volume of the ascending aorta and adenosine (0.25 mg/kg) manually syringe-flushed through the device port to achieve rapid diastolic cardiac arrest (Figure 7A). The balloon is then fully inflated under TEE guidance and positioned between the sinotubular ridge and innominate artery (Figure 7B) while antegrade cardioplegia is delivered and monitored by aortic root- and cardioplegic line pressures. The retrograde CPB inflow will push the balloon towards the aortic valve and it is import to pull the device back under TEE guidance to ensure it remains at the sino-tubular junction. It is then locked in position while ensuring satisfactory right arterial line pressures. Endoscopic visualisation and palpation of the aorta with a rigid sucker confirm TEE positioning (Figure 7C). Sudden loss of radial artery trace suggests innominate artery obstruction due to dislodgement and requires rapid repositioning. Even though the safety of current PAS technology compared to direct external aortic clamping strategies utilized in MIAS are well described (42-45), emerging centres should also be familiar with alternative external aortic clamping-, cardioplegia delivery and antegrade venting techniques. Following the placement of a long antegrade venting / cardioplegia needle into the ascending aorta, the transverse sinus is carefully developed with blunt dissection and an external aortic clamp carefully introduced through a separate port to cross-clamp the aorta under endoscopic vision (Figure 7D). The clamp is applied without injuring the pulmonary artery or left atrial appendage. The infrequent application of ventricular fibrillation should also be mentioned. Conversion to sternotomy is strongly advocated if any difficulties are anticipated or occur.

Figure 7 Antergrade cardioplegic arrest. (A) Intraclude™ inflation while ensuring the device position remains at the sino-tubular junction under (B) transoesophageal echocardiographic guidance, which is followed by (C) manual confirmation of the device position. (D) External aortic clamping across the transverse sinus with antegrade cardioplegia and venting.

Atriotomy and valve exposure (Figure 8)

Figure 8 Restractor placement (46). Available online:

Following a generous left atriotomy (Figure 9A), a left atrial retractor with collapsing side arm (USB medical, Hartboro, USA) is inserted into the left atrium, followed by the placement of a cardiotomy vent into the left superior pulmonary vein (Figure 9B). The retractor blade angle can be manually adjusted to ensure unobstructed endoscopic visualization and single shaft instrument access to the mitral valve (MV) and it is recommended to invest adequate time and effort in establishing optimal visualization for procedural ease, especially for suture placement in the anterior MV annulus. Superior- and inferior vena cava occlusion is required for safe right atriotomy and can be achieved with clamps, tape-snares or endoballoon occlusion (Reliant™, Medtronic, Minneapolis, USA) through the internal jugular- and femoral vein respectively. Experienced centres may only use femoral vein cannulation and by retracting the cannula into the inferior vena cava with careful vacuum assisted drainage and flow adjustments, obtain access to the tricuspid valve (TV). It is advocated that emerging centres utilise bicaval venous drainage and safe caval occlusion. Modified TV-retractors or exteriorising sutures can be utilised to obtain easy access and working angles. For intraatrial neoplasm excision, the risk of fragmentation may prohibit the use of an atrial retractor and visualization can subsequently established by traction sutures. In pronounced pectus excavatum deformities, the retractor may be positioned on the left parasternal border. The antero-posterior retraction distance between the right atrium and anterior chest wall may be extremely limited and additional manoeuvers are required to facilitate exposure, which include tilting the patient maximally to the left while applying low positive end-expiratory pressure to the left lung.

Figure 9 Valve exposure and analysis. (A) Left atriotomy; (B) intraatrial retractor placement; (C) systematic valve analysis.

Intraatrial and AVV procedures (Figures 10,11)

Figure 10 Annular sutures (47). Available online:
Figure 11 Knotting (48). Available online:

Large PAS series report the incidence of isolated MV-, isolated TV and combined MV and TV procedures to be 76.0%, 1.9% and 22.1% respectively (40). It is advocated that simple isolated MV or TV procedures are selected during the initial learning experience. The findings of a through intraoperative intraatrial inspection and systematic valve analysis should correlate with the pathology identified by preoperative TEE (Figure 9C). Routine sub-valvular, valvular and annular repair- and replacement procedures can be performed using special long shafted instruments. In cases of MV repair, it is suggested that sub-valvular neochords (Gore-Tex™, Gore & Associates Inc., Arizona, USA) are placed first if required and that annulaplasty suture placement start at P1 progressing up to mid-A2 segment (Figure 12A). Possible IntraClude™ rupture can occur with deep suturing in this zone and requires awareness. Experienced centres advocate the use of additional traction maneuvers, which include a retracting steel wire, to improve MV exposure. Segments P3 to mid-A2 sutures are subsequently placed, followed by the remainder of P1 to P3 (Figure 12B). This sequence prevents distortion of the annulus and allows for perfect exposure. The valve is appropriately sized (Figure 12C) and then parachuted into position. The technique of knot tying deserves special mention (Figure 13A), as long shafted knot-tying devices require continuous suture tension provided by the surgical assistant and good coordination between the surgeon and assistant (Figure 13B). Knotting devices (e.g. Core-knot™, LSI solutions, New York, USA; other options exist) can also be utilised. Experienced centres report a 96.4% MV repair success for primary annular dilatation and degenerative valves, with MV- (Figure 14A) and TV (Figure 14B) repair procedures constituting 82% of experienced PAS program (40). Simple atrial septal defects can be corrected with appropriately sized patch closure (Figure 15A). The base of intraatrial neoplasms is widely excised without manipulation and any defects reconstructed accordingly. Cryoablation for atrial fibrillation (Figure 15B) is performed with an argon-gas surgical ablation system (Medtronic, Minneapolis, USA) prior to annuloplasty suture placement and patent foramen ovale (PFO) routinely closed in 2 layers with a running 3-0 polypropylene suture.

Figure 12 Endoscopic annular suture placement and sizing. (A) Systematic annular suture placement from P1- to mid-A2 segment; (B) completed annular suture placement; (C) valve ring sizing.
Figure 13 Annular ring suture knotting. (A) Extrathoracic valve knotting with a surgical assistant and subsequent; (B) sliding of the knot onto the annular ring.
Figure 14 Complex repair of (A) mitral- and (B) tricuspid valve.
Figure 15 Non-atrioventricular valve procedures considered safe for initiating a Port Access™ program include (A) simple atrial septal defect patch closure and (B) cryoablation for atrial fibrillation.

De-airing and procedure conclusion

Once the intended procedure is satisfactory completed, the left superior pulmonary venting catheter is positioned across the MV into the left ventricle and the left atrium closed with two running 3-0 polypropylene sutures from the superior- and inferior incision apex respectively, which is initially snared with the vent across the mitral valve and subsequently tied once the vent is removed. De-airing under TEE guidance is achieved by filling of all cardiac chambers, antegrade aortic root venting through the IntraClude™ device and left ventricular venting through the cardiotomy suction vent in conjunction with continuous CO2 insufflation of the right hemithorax. A temporary epicardial pacing wire is placed on the left ventricular diaphragmatic surface before deflating the IntraClude™ device with the patient in Trendellenburg position. Once general intraoperative parameters are stable and systematic TEE valve- and contractility analysis confirm satisfactory results and are satisfactory, CPB is discontinued and the deflated IntraClude™ device carefully removed. Femoral venous decannulation is performed first, followed by femoral artery decannulation once volume infusions are completed. Post-decannulation femoral artery patency should be confirmed by duplex-Doppler or pulse palpation and any distal perfusion concerns should be immediately addressed by either contrasted angiography and/or reexploration. The cardiotomy suction venting- and atrial retracting incisions are utilised for drainage tubes into the pericardium and hemithorax. The pericardium is subsequently loosely approximated and all wounds sutured in layers to prevent subcutaneous surgical emphysema or lung herniation. Postoperative cardio-respiratory support, sedation, analgesia and other appropriate medication are continued in intensive care, with an individualised in-hospital treatment pathway supervised by a multidisciplinary team.

Overcoming specific learning curves and the potential role of simulation training

Simple atrial septal defect-, intraatrial myxoma- and uncomplicated valve procedures are preferred procedures during the initial learning curve. Hunter (31) identified AVV repair techniques, TEE-guided cannulation, incision placement and setup, transition to single shaft instrument use, AVV visualization and CPB strategies as seven key aspects that contribute to a steep learning curve. The importance of a team consensus on time limit definitions where (49) identified the typical number of operations to overcome the learning curve to range between 75 and 125 procedures and further suggested that more than 1 procedure per week is required to maintain acceptable results. De Praetere (50) reported the learning curve to be 30 procedures, with a significant reduction in aortic cross-clamp time before and after the end of the learning curve. In an era of decreasing surgical volume, simulation team training is strongly advocated (Figure 16).

Figure 16 Port Access™ simulations.

Future perspectives and conclusion

TC and MIAS technology will continue to evolve and efforts to simplify these platforms will continue as robotic technology-, instrumentation and imaging modalities develop. PAS is proven to be safe and effective for simple and complex AVV surgery and is considered to be a reliable alternative to meet increasing patient demands for less invasive surgical procedures within the context of healthcare trends that aim limits cost-, time- and hospital resources. Experienced centres offer PAS without exclusion criteria, but careful planning and implementation of new programs should focus on risk management and excellent outcomes. Patients are the greatest advocates of a successful PAS program and every effort to reduce adverse outcome risk within a team context should be priority.




Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.


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doi: 10.21037/jovs.2019.08.01
Cite this article as: Van der Merwe J, Casselman F, Van Praet F. The principles of minimally invasive atrioventricular valve repair surgery utilizing endoaortic balloon occlusion technology: how to start and sustain a safe and effective program. J Vis Surg 2019;5:72.