Uniportal video-assisted thoracoscopic surgery in esophageal diseases: an introduction
Review Article on Esophageal Surgery

Uniportal video-assisted thoracoscopic surgery in esophageal diseases: an introduction

Toni Lerut

Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium

Correspondence to: Toni Lerut. Emeritus Professor of Surgery; Emeritus Chairman Department of Thoracic Surgery, University Hospital Leuven, Belgium. Email: Toni.lerut@med.kuleuven.be.

Abstract: Esophagectomy followed by reconstruction is one of the most complex interventions in surgery of the alimentary tract. Over several decennia dedicated surgeons have realized a constant decrease in 30-day mortality being now well below 5% in expert hands. However quality of life after such intervention is often jeopardized by the high incidence of complications in particular pulmonary infections. The introduction and presently widespread use of total minimally invasive esophagectomy (MIE) has re resulted in a substantial decrease of these pulmonary complications along with a decrease of the need for ICU admission and a decrease of length of hospital stay. But still a non-negligible share of patients may suffer from, sometimes severe, posthoracotomy pain. A problem that is thought to be the result of the manipulation of instruments at the port sites causing damage to the intercostal nerves. The growing popularity of uniportal video-assisted thoracoscopic surgery (VATS) in particular in lung surgery claims to diminish this problem. Currently there is little experience in the use of uniportal VATS for esophagectomy which seems to be in part related to its higher degree of technical complexity. As a result there are no published data on the results but there are a few dedicated centers that are building up their experience. Their preliminary results seem to hold promising perspectives in relation to overcome the pain problem using a single small port site. Future will tell what the place will be of uniportal VATS versus other techniques e.g., robotic esophagectomy, endoscopic interventions on the esophagus and new emerging avenues in molecular biology.

Keywords: Esophagus; surgery; minimally invasive esophagectomy (MIE); uniportal VATS; complications; quality of life


Received: 20 October 2017; Accepted: 06 November 2017; Published: 07 December 2017.

doi: 10.21037/jovs.2017.11.04


The end of the 19th century was characterised by a true race to perform the first esophagectomy.

Franz Torek (1) won the race by performing the first successful transthoracic (and transpleural) resection of the esophagus in 1913. The operation was a formidable undertaking. The patient, a woman, presented with a mid-third squamous cell carcinoma. During surgery the tumor appeared to be attached to the left bronchus requiring a “longitudinal cut in the bronchus” followed by a repair if this incision with silk sutures. Reconstruction was not attempted and the patient was fed using a rubber tube connecting the proximal esophagostomy with a gastrostomy; she lived for 13 years.

Further attempts made in the following years were mostly unsuccessful due to lack of technology to adequately ventilate the lungs. Only after the introduction of safe orotracheal intubation in the late twenties by Rowbotham (2) and Magill (3) surgeons could undertake more safely such complex operation as a transthoracic esophagectomy. Torek’s operation was performed via left thoracoabdominal incision. In the subsequent years surgeons figured out that according to the location of the tumor different access routes could improve exposure and access to the tumor. Tumors of the lower half were preferentially approached from the left side (4,5) whereas supracarinal tumors were better approached from the right side (6,7).

Refinement of technique resulted in a gradual decrease of the mortality coming down from over 20% in the seventies to less than 10% in the eighties.

But esophagectomy and reconstruction mostly with a gastric pull up with an intrathoracic or cervical anastomosis remained major interventions the results often jeopardized by postoperative complications e.g., anastomotic leaks, pulmonary infection causing prolonged hospitalization and slow recovery.

In an effort to minimize complications, in particular pulmonary complications Orringer in 1978 introduced the concept of transhiatal esophagectomy i.e., removal of the esophagus without opening the chest (8).

This approach quickly gained popularity not in the least amongst general surgeons being less familiar with thoracic interventions. Transhiatal esophagectomy however was criticized because it was thought to be a less safe oncologic intervention not allowing for a proper intra thoracic lymphadenectomy.

The introduction of videoscopic minimally invasive, so called key hole, surgery in the late eighties created new perspectives. Cuschieri is to be credited for having performed the first thoracoscopic esophagectomy in 1992 (9).

But it is Luketich who really brought the totally minimally invasive esophagectomy (MIE) into the surgical practice (10).

With the rapid growing experience it became clear that MIE indeed results in a significant decrease in postoperative complications in particular pulmonary complications (11,12) in its turn resulting in a significant decrease of ICU stay, decrease in length of hospital stay and a clear improvement in postoperative rehabilitation and related quality of life (13,14).

But nevertheless a minority of patients may suffer from prolonged “post-thoracotomy” pain at the site of the small port incisions. This problem is thought to be the result of the manipulation of the scope and instruments through these small intercostal spaces causing potential damage to the intercostal nerves (13).

So surgeons have been exploring methods to minimize this sometimes debilitating complication by e.g., introducing pleural catheters delivering prolonged anesthetic fluid in the vicinity of the intercostal nerve. But the results are not unequivocally satisfactory.

The credit goes to Marcello Migliore from Catania to introduce to the thoracic surgical community the concept of uniportal video-assisted thoracoscopic surgery (VATS) (15). Through one somewhat larger incision different instruments can be introduced through this single port which has a larger intercostal space because of its more anterior location on the chest wall.

The concept was rapidly picked up and gained popularity not in the least part through media coverage. Uniportal VATS is mainly used in pulmonary surgery. A recent systematic review comparing uniportal VATS lobectomy versus multiportal VATS lobectomy seems to indicate an outcome in favour of the uniportal VATS lobectomy in terms of the overall rate of complications, length of hospital stay and duration of postoperative drainage (16). However there are indications that uniportal VATS lobectomy does not present better outcomes in relation to pain sensation on visual pain scale and use of morphine in the first postoperative days (17). Clearly future has to tell whether the uniportal VATS lobectomy is superior to the multiportal one and importantly oncologically as safe.

Because the complexity of esophagectomy and reconstruction there is till now almost no data in literature on the use of uniportal VATS esophagectomy.

Dmitrii et al. (18) describe the technique of uniportal esophagectomy in a very recent publication but without further reporting on their experience and results. Presumably the largest experience has been built up by Hasan Batirel from Marmara University, Istanbul now exceeding several tens of esophagectomies. His technique of uniportal VATS esophagectomy will be described in detail this issue.

I have seen Prof. Batirel at work several times over the last few years and witnessed his progress from the very beginning of his experience. A first observation is that there is a steep learning curve even in a center with a large experience with esophagectomy for cancer.

Furthermore it appears that the uniportal approach is more difficult than the multi portal approach because in the latter it is easier to manipulate the esophagus. And finally crowding of the instruments through the unique small incision seems to be more problematic as compared to uniportal VATS lobectomy presumably because the location of the esophagus in the posterior mediastinum requiring more constant need for retraction of both lung tissue and esophagus. This inevitably also results in crowding of the hands of the two surgeons.

But all the surgeries that I observed were quality wise matching what is observed during multiportal esophagectomies.

To remediate the crowding of instruments and hands geometrical thinking patterns have been proposed to overcome the problem but the reality looks less prosaic to me (19).

The main question is where to position the role of uniportal esophagectomy and what will be its future.

There seems to be an increasing trend to look into the possibilities to either omit chest tubes or to replace the classic chest tubes by tubes that are flatter and smoother. Indeed chest tubes are seen as another potential culprit of post-thoracotomy pain. If newer designs of tubes or even no tubes at all could indeed reduce the incidence and/or intensity of pain it may well be favoring the proponents of the 2 or multiport approach especially in the era of ERAS (20).

Certainly in the area of esophagectomy for cancer there is surge on publications dealing with enhanced recovery protocols. It remains to be seen how uniportal versus 2 or multiportal approaches will fit in these protocols.

Another challenge for the uniportal VATS is the robotic VATS, now called RATS (21), also again in part because of the media coverage of this technology.

It is claimed that using robotic instruments will result in less manipulation and/or traumatization of the intercostal nerves. And by definition uniportal approaches are not apt to the use of robotic approach.

Obviously much more studies and in particular long term follow results are needed to really judge the value of all these new evolving technologies and tools.

Surgeons throughout all times have been very inventive and creative but to quote Ronald Belsey one of the great giants in thoracic surgery: ‘The battlefields of surgery are strewn with the remains of promising new operations which perished in the follow-up clinic’. It is therefore a duty of thoracic surgeons, in particular in the academic centers, to embrace all reasonable new technologies or tools in order to use them, evaluate them and objectively report on the advantages and disadvantages.

Besides all these emerging surgical technologies a similar evolution can be seen on the side of the interventional non-surgical area. The recent introduction of POEM (peroral endoscopic myotomy) in the treatment of Achalasia has clearly challenged the classic Heller-Dor myotomy (22). The endoluminal suturing device Overstitch from Apollo Endosurgery now allows for the first time to realize the placement of a continuous suture line via the endocope, very much similar to a classical surgically placed one (23).

In cancer of the esophagus the introduction of biologicals has opened very promising perspectives possible leading to non-surgical therapy of esophageal cancer.

Combining surgical and medical nanotechnology is no longer science fiction.

From all this it must become clear that there is a definite need for super-specialization in the field of esophageal pathology both benign and malignant.

The surgeon of tomorrow dealing with esophageal cancer will work in close collaboration with his/her peers in oncology, interventional radiology, interventional endoscopy.

And within this context the position of the surgeon of the future will require not only persistent creativity in designing new techniques in creating new technologies but also will require more than ever the ability of the surgeon to master the knowledge of esophageal diseases and to master the specifics of diagnosis and therapy (including complications and failure) in order to offer the best possible solution tailored on the profile of each individual patient.


Acknowledgements

None.


Footnote

Conflicts of Interest: The author has no conflicts of interest to declare.


References

  1. Torek F. The first successful case of resection of the thoracic portion of the esophagus for carcinoma. Surg Gynecol Obstet 1913;16:614-7.
  2. Rowbotham S. Laryngeal intubation in anaesthetics. Br Med J 1923;1:1090-1. [Crossref] [PubMed]
  3. Magill IW. Endotracheal Anæsthesia. Proc R Soc Med 1928;22:83-8.
  4. Sweet RH. Carcinoma of the esophagus and the cardiac end of the stomach immediate and late results of treatment by resection and primary esophagogastric anastomosis. J Am Med Assoc 1947;135:485-90. [Crossref] [PubMed]
  5. Belsey RH. Surgical exposure of the esophagus. In: Skinner DB, Belsey RH. editors. Management of Esophageal Disorders. Philadelphia, London, Toronto, Montreal, Sydney, Tokyo: WB Saunders Company, 1988:192-201 and 757.
  6. Lewis I. The surgical treatment of carcinoma of the oesophagus; with special reference to a new operation for growths of the middle third. Br J Surg 1946;34:18-31. [Crossref] [PubMed]
  7. McKeown KC. Total three-stage oesophagectomy for cancer of the oesophagus. Br J Surg 1976;63:259-62. [Crossref] [PubMed]
  8. Orringer MB, Sloan H. Esophagectomy without thoracotomy. J Thorac Cardiovasc Surg 1978;76:643-54. [PubMed]
  9. Cuschieri A, Shimi S, Banting S. Endoscopic oesophagectomy through a right thoracoscopic approach. J R Coll Surg Edinb 1992;37:7-11. [PubMed]
  10. Luketich JD, Alvelo-Rivera M, Buenaventura PO, et al. Minimally invasive esophagectomy: outcomes in 222 patients. Ann Surg 2003;238:486-94; discussion 494-5. [PubMed]
  11. Nafteux P, Moons J, Coosemans W, et al. Minimally invasive oesophagectomy: a valuable alternative to open oesophagectomy for the treatment of early oesophageal and gastro-oesophageal junction carcinoma. Eur J Cardiothorac Surg 2011;40:1455-63; discussion 1463-4. [PubMed]
  12. Biere SS, van Berge Henegouwen MI, Maas KW, et al. Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Lancet 2012;379:1887-92. [Crossref] [PubMed]
  13. Maas KW, Cuesta MA, van Berge Henegouwen MI, et al. Quality of Life and Late Complications After Minimally Invasive Compared to Open Esophagectomy: Results of a Randomized Trial. World J Surg 2015;39:1986-93. [Crossref] [PubMed]
  14. Kauppila JH, Xie S, Johar A, et al. Meta-analysis of health-related quality of life after minimally invasive versus open oesophagectomy for oesophageal cancer. Br J Surg 2017;104:1131-40. [Crossref] [PubMed]
  15. Migliore M, Deodato G. A single-trocar technique for minimally-invasive surgery of the chest. Surg Endosc 2001;15:899-901. [Crossref] [PubMed]
  16. Harris CG, James RS, Tian DH, et al. Systematic review and meta-analysis of uniportal versus multiportal video-assisted thoracoscopic lobectomy for lung cancer. Ann Cardiothorac Surg 2016;5:76-84. [Crossref] [PubMed]
  17. Perna V, Carvajal AF, Torrecilla JA, et al. Uniportal video-assisted thoracoscopic lobectomy versus other video-assisted thoracoscopic lobectomy techniques: a randomized study. Eur J Cardiothorac Surg 2016;50:411-5. [Crossref] [PubMed]
  18. Dmitrii S, Pavel K. Uniportal Video-Assisted Thoracic Surgery Esophagectomy. Thorac Surg Clin 2017;27:407-15. [Crossref] [PubMed]
  19. Bertolaccini L, Viti A, Terzi A, et al. Geometric and ergonomic characteristics of the uniportal video-assisted thoracoscopic surgery (VATS) approach. Ann Cardiothorac Surg 2016;5:118-22. [Crossref] [PubMed]
  20. Ismail M, Swierzy M, Nachira D, et al. Fast-Tracking Patients Through the Diagnostic and Therapeutic Pathways of Intrathoracic Conditions: The Role of Uniportal Video-Assisted Thoracic Surgery. Thorac Surg Clin 2017;27:425-30. [Crossref] [PubMed]
  21. Yang S, Guo W, Chen X, et al. Early outcomes of robotic versus uniportal video-assisted thoracic surgery for lung cancer: a propensity score-matched study. Eur J Cardiothorac Surg 2017. [Epub ahead of print]. [Crossref] [PubMed]
  22. Li QL, Zhou PH. Perspective on peroral endoscopic myotomy for achalasia: Zhongshan experience. Gut Liver 2015;9:152-8. [Crossref] [PubMed]
  23. Kurian AA, Bhayani NH, Reavis K, et al. Endoscopic suture repair of full-thickness esophagotomy during per-oral esophageal myotomy for achalasia. Surg Endosc 2013;27:3910. [Crossref] [PubMed]
doi: 10.21037/jovs.2017.11.04
Cite this article as: Lerut T. Uniportal video-assisted thoracoscopic surgery in esophageal diseases: an introduction. J Vis Surg 2017;3:182.

Refbacks

  • There are currently no refbacks.